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In Situ Transmission Electron Microscopy: Experimental Design and Practice

為了解決s design的問題，作者Hattar, Khalid,Sharma, Renu 這樣論述：

Dr. Khalid Hattar is a Principal Member of the Technical Staff in the Ion Beam Lab and Center for Integrated Nanotechnologies at Sandia National Laboratories in Albuquerque, New Mexico. He received a B.S. in Chemical Engineering with an emphasis in Materials Science from University of California, Sa

nta Barbara in 2003, and a Ph.D. in Materials Science and Engineering from University of Illinois, Urbana-Champaign in 2009 under the guidance of Professor Ian M. Robertson. He specializes in determining the property-microstructure relationship for a variety of structural and functional materials th

rough in situ electron microscopy techniques in various extreme environments, as well as tailoring local properties of materials through ion beam modification. This includes the development of the In-situ Ion Irradiation Transmission Electron Microscope that is designed to explore a range of juxtapo

sed conditions. He has given 74 invited presentations, published three book chapters, and over 100 research articles. Dr. Renu Sharma is a Project Leader in the Physical Measurement Laboratory at National Institute of Standards and Technology (NIST). She received a B.S. and B.Ed. in Physics and Chem

istry from Panjab University, India, and M.S. and Ph.D. degrees in Solid State Chemistry from the University of Stockholm, Sweden. She joined NIST in 2009 as a Faculty Research Associate in the Department of Chemistry and Biochemistry and the Center for Solid State Science. She is a pioneer in the d

evelopment of environmental scanning transmission electron microscopy (E(S)TEM), combining atomic-scale dynamic imaging with chemical analysis to probe gas-solid reactions. She has received a Bronze Medal of Service from Department of Commerce for developing new measurement techniques. She has given

over 90 invited presentations, edited one book, published 5 book chapters and over 200 research articles. At the NIST, she established an advanced E(S)TEM measurement capabilities, that combines Raman spectroscopy, cathodoluminescence with electron diffraction, electron spectroscopy, high-resolutio

n imaging and plasmonics, applied in nanoscience research.

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區塊鏈技術在台灣二手車市場應用之實證研究

為了解決s design的問題，作者蘇祐 這樣論述：

近年來的二手車市場交易量皆比新車市場高的多，且每年逐漸上升，此市場日益壯大，價格機制卻還是相當混亂，相當不透明，故此本研究以改善台灣二手車市場資訊不對稱問題為發想，設計一套網頁系統，以以太坊區塊鏈為系統底層，且成立一個二手車聯盟來管理該系統，有意願加入此系統的車主需將車輛移至與聯盟配合之檢修場，在確認資料無誤後，聯盟會將該車輛的資料上傳至區塊鏈系統上，以供系統參與者查閱。 本研究透過設計區塊鏈系統進行實作實驗，依據區塊鏈的不可篡改性來用以改善台灣二手車市場資訊不對稱問題，並使用Node.js SDK工具提供網頁客戶端，模擬車輛資料上傳的流程，最後提出三項實驗數據以檢驗新的系統架構設計適確性

，以及檢驗資料的正確性。實驗結果顯示，本研究所提出之二手車區塊鏈系統確實可改善二手車市場資訊不對稱的問題，藉由區塊鏈的不可篡改性，讓資料上傳後就無法修改，就算覆蓋過去鏈上也都能查到相對的紀錄，確保鏈上資料的正確性，讓其餘參與者在系統上查閱時，能夠信任這份資料，進一步改善過去消費者只能以車主所提供之資料作為參考，讓二手車市場資訊更加透明，進一步提高消費者對市場的滿意度及忠誠度。

Slouching Towards Los Angeles: Living and Writing by Joan Didion’’s Light

為了解決s design的問題，作者 這樣論述：

L.A.-based writer and editor Steffie Nelson has covered art, design and culture for The New York Times, the Los Angeles Times, W Magazine, LA Review of Books and others. She recently co-authored Judson: Innovations in Stained Glass (Angel City Press) and is currently developing Cosmic City: The Hist

ory of Seekers in Los Angeles. www.steffienelson.com

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決s design的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.