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高頻電針合併耳穴按壓治療海洛因使用者之睡眠品質研究

為了解決neuropeptide中文的問題，作者虞凱強 這樣論述：

口服美沙酮維持治療被視為注射型海洛因的重要替代療法，跟美沙酮不良反應包含嚴重失眠，造成再次使用海洛因風險提高，針灸被醫學證實針刺穴位可降低患者使用美沙酮劑量、提高睡眠品質療效。本次試驗是採用交叉試驗的設計，於北市聯醫昆明院區4樓美沙酮門診收案(人體研究倫理審查委員會認證號碼: TCHIRB-10601106)，以隨機之亂數表分成A組（電針合谷（LI4），電針足三里（ST36）並按壓耳神門穴）和B組（僅按壓耳神門穴）。每週進行二次治療，持續4週。在一周廓清期後，進行各組的交叉治療。主要評估為四次測量值，最後以合併與單一治療組做比較:(1)睡眠品質量表，(2)生活品質量表(包含生理、心理比較、附

件8)，(3)美沙酮劑量比較。總共收案人數50人，未完成試驗人數有13人，完成試驗總共有37人。合併治療相較於單一治療組有較佳的睡眠品質，例如:主觀睡眠質量（61.11％vs. 20.93％，p

利用腦部磁振造影輔助偏頭痛診療用藥之研究

為了解決neuropeptide中文的問題，作者賴碧儀 這樣論述：

中文摘要 iAbstract iiTable of Contents iiiList of Figures viList of Tables viiChapter 1 Introduction 11.1 Migraine Background 11.1.1 Classification and Symptoms 11.1.2 Prevalence and Burden 21.1.3 Onset Age 31.1.4 Pathophysiology 41.1.5 Diagnosis 81.1.6 Treatment

91.1.7 Treatment Response of Triptans 121.1.8 Sumatriptan Responders 141.2 Structural and Functional Magnetic Resonance Imaging (MRI) 141.3 Neuroimaging for Migraine 191.4 Machine Learning 281.5 Motivation and Purpose 30Chapter 2 Material and Method 312.1 Data Collection 312.

1.1 Subjects 312.1.2 Inclusion Criteria 312.1.3 Exclusion Criteria 322.1.4 Measures of Sumatriptan Response 322.1.5 Questionnaire Data 332.2 MRI Acquisition 342.2.1 Structural MRI Study 342.2.2 Functional MRI Study 342.3 Data Processing 352.3.1 Structural MRI Data Preproce

ssing 352.3.2 Image Processing by FreeSurfer 362.3.3 Voxel-Based Morphometry (VBM) 372.3.4 Resting State fMRI Data Processing 382.3.5 Functional Connectivity 392.4 Statistics 402.4.1 Demographic Data Analysis 402.4.2 Analysis of Cortical and Subcortical Features 402.4.3 VBM A

nalysis 412.4.4 ReHo and fALFF Analysis 412.4.5 Whole-Brain rsFC Analysis 412.5 Machine Learning 41Chapter 3 Results 443.1 Demographics 443.1.1 Structural Study 443.1.2 Functional Study 453.2 Morphometry Results 463.2.1 Cortical and Subcortical Volume 473.2.2 Voxel-base

d morphometry (VBM) Result 493.3 rsfMRI results 503.3.1 ReHO and fALFF Analysis 503.3.2 Resting-State Functional Connectivity Analysis 503.4 Machine Learning 62Chapter 4 Discussion 644.1 Sumatriptan Efficacy in Migraine Patients with Hippocampal Volume 644.2 Sumatriptan Efficacy

in Migraine Patients with functional connectivity of DMN and cerebellum 664.2.1 The implication of the cerebellar DMN connectivity in sumatriptan treatment response 664.2.2 Two hypotheses of the altered cerebellar DMN connectivity in sumatriptan treatment response 684.2.3 Possible associat

ion with pain modulation via specific brain regions of DMN intra-network 694.3 Limitation 694.4 Scope for Future Work 70Conclusions 72Reference 74