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Holistic nursing：what the feet can Tell (未來健康：腳會說話(英文版))

為了解決TEAM WANG STANDARD的問題，作者Shwu-FengTsay,Chi-WangHu 這樣論述：

　　腳為什麼會說話？應用區帶療法，反射學定位了相對全身解剖生理系統之足部相對應反射部位，透過對足部觀察、手法觸覺、溝通會談等評估足部89個反應區所傳遞相對全身系統的健康資訊及身體經年累月的壓力負荷線索，再透過專業定位與沉力手法或足療棒法，去緩解足部反應區的阻塞，讓身體原有的機能得以復原與調整，以達健康促進及疾病預防，而健康促進與疾病預防正是「未來健康」的關鍵與願景。   　　護理的身心靈全人照護觀是影響照護品質的關鍵，照護是複雜的生理、心理、社會調整過程，如何以人為中心，回應人身體、情緒、社會及靈性的需求，協助身心靈的調適與平衡，是本書的核心論述。衛福部出版「未來健康：腳會說話」一書，提供

護理人作為疼惜自已及疼惜他人的重要保健手冊。

TEAM WANG STANDARD進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決TEAM WANG STANDARD的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

Regional Geological Survey of Hanggai, Xianxia and Chuancun, Zhejiang Province in China: 1:50,000 Geological Maps

為了解決TEAM WANG STANDARD的問題，作者Zhang, Jianfang,Zhu, Chaohui,Wang, Longwu 這樣論述：

This Open Access book introduces readers to the regional geology of Hanggai, Xianxia and Chuancun, the area between China's northern Zhejiang Province and southern Anhui Province and explores the strata, magmatic rocks and tectonic structures in 1:50,000 scale geological maps. Based on studies of mu

ltiple stratigraphic divisions, the standard stratigraphic section of the upper Ordovician Hirnantian in the lower Yangtze region is established, revealing for the first time numerous "Burgess Shale-type" sponge fossils in Hirnantian strata and identifying 10 grapholite fossil belts and various foss

il categories, including chitin, trilobites, gastropods, brachiopods, and cephalopods. Moreover, the book identifies for the first time Late Ordovician volcanic events in northern Zhejiang province. The work represents a major contribution to research on Paleozoic strata in the Lower Yangtze region,

and sheds new light on understanding the Hirnantian glacial event and biological extinction event in South China by providing a high-precision time scale. In addition, the book opens an important avenue for future research on sponge evolution after the Cambrian life explosion. As such, it offers a

unique and valuable asset for researchers and graduate students alike. Jianfang ZHANG, an engineer. He was in charge of 3 large and medium-sized projects and participated in 4 projects during his work at regional geological and mineral survey in the north of Zhejiang Province, which are founded by

China Geological Survey and Department of Land and Resources of Zhejiang Province. He led a team work on the Paleozoic multiple stratigraphic division, Mesozoic magmatic rocks and mineralization. Moreover, he creats a new way for geological maps expressing and achieved remarkable results and good s

ocial benefits. The Project ＂1:50000 Regional Geological Survey in Hanggai, Xianxia and Chuancun, Zhejiang Province＂ was evaluated as one of the top ten excellent geological work in ＂Twelfth Five-Year Plan＂ in Zhejiang Province.Chaohui Zhu, a senior engineer. He has long been engaged in regional geo

logical and mineral surveys and project management research. He has high attainments in the study of the genesis of Mesozoic volcanic rocks in South China, innovation in technical method for geological survey, project management. Moreover, he promoted the investigation and research of Mesozoic volca

nic rocks in Zhejiang.Longwu Wang, Professor-level senior engineer. He has long been engaged in regional geological survey, mineral exploration, and the quality management of geological project. He has deep theoretical understanding and high reputation in multiple stratigraphic divisions and made gr

eat contributions to strata study in Zhejiang.Xiaoliang Cai, an engineer. He has long been engaged in regional geological survey, mineral exploration, and geochemical surveys. In recent years, with the development of digital technology in geological Survey, he completed a number of geological maps,

mineral geological maps and geochemical maps, and contributed to the standardization of geological data.Ruijun Gong, an engineer. She has long been engaged in soil geochemical investigation and regional stream sediment geochemical survey.Xiaoyou Chen, a senior engineer, has long been engaged in the

regional geological survey and mineral geological investigation in the Mesozoic volcanic rocks in South China.Jianguo Wang, a senior engineer, has long been engaged in geological mapping in the Zhejiang orogenic belt. He and his team compiled the first 1:50000 scale geological map in Zhejiang, refle

cting the geological theory of the ocean plate, and it has a good demonstration effect on the mapping the block of oceanic plate in the orogenic belt. He reconstructed the geotectonic framework of the Jiangshan-Shaoxing conjunction zone and made significant contributions to the research of geologica

l structure in South China.Mingguang Gu, a professor-level senior engineer, has long been engaged in regional geology and urban geological surveys.Zongyao Zhou, a senior engineer, has long been engaged in regional geology, mineral exploration and the quality management of geological project.Yuandong

Liu, an engineer, has long been engaged in the investigation and research of volcanic rocks in the Mesozoic in South China.

臺灣港埠引水安全精進策略之研究

為了解決TEAM WANG STANDARD的問題，作者許忠盈 這樣論述：

目錄中文摘要 ----------------------------------------------------------------------I英文摘要 ---------------------------------------------------------------------II誌謝-------------------------------------------------------------------------III目錄-----------------------------

---------------------------------------------IV表目錄-----------------------------------------------------------------------VII圖目錄----------------------------------------------------------------------VIII第一章 緒論-------------------------------------------------------------------11.1 研究背景與動機------------

----------------------------------------------11.2 研究目的---------------------------------------------------------------21.3 研究範圍與限制----------------------------------------------------------21.4 研究方法---------------------------------------------------------------3第二章 臺灣引水制度之沿革與現況-------------------

------------------------------42.1 引水之意涵與目的--------------------------------------------------------42.1.1 從法制面向分析----------------------------------------------------------52.1.2 從港埠經營面向分析------------------------------------------------------82.2 引水人的角色功能------------------------------------------

--------------92.2.1 引水人之角色定義--------------------------------------------------------92.2.2 引水人關於航行安全之角色功能--------------------------------------------112.2.3 引水人關於監督船舶與船員之角色功能---------------------------------------122.2.4 引水人關於港埠服務之角色功能--------------------------------------------132.2.5 引水人關於港埠

效率之角色功能--------------------------------------------162.3 臺灣引水制度之沿革-----------------------------------------------------172.4 臺灣引水制度現況-------------------------------------------------------192.4.1 強制引水與自由引水之實施現況--------------------------------------------192.4.2 引水人之資格、培訓與執業----------------------

--------------------------212.4.3 引水費率--------------------------------------------------------------232.4.4 引水之監理------------------------------------------------------------252.4.5 各港引水人選任與執業人數現況--------------------------------------------30第三章 臺灣港埠引水環境之變革----------------------------------------

---------343.1 國際公約對臺灣港埠引水環境的牽動----------------------------------------343.1.1 IMO早期決議案---------------------------------------------------------363.1.2 SOLAS之相關規定-------------------------------------------------------373.1.3 STCW之相關規定--------------------------------------------------------443.1.

4 IALA之相關規定--------------------------------------------------------463.2 海域空間使用多元-------------------------------------------------------473.2.1 遊艇------------------------------------------------------------------483.2.2 渡輪------------------------------------------------------------------503.2.3

漁船------------------------------------------------------------------523.3 船舶大型化與快速化-----------------------------------------------------533.3.1 港埠營運步調的變動-----------------------------------------------------583.3.2 港埠設施規劃-----------------------------------------------------------583.3.3 船員對引水人的依

賴性增加------------------------------------------------603.4 航運效益日漸嚴峻-------------------------------------------------------613.4.1 引水協力資源的強化-----------------------------------------------------623.4.2 航商對引水成本的關注效應------------------------------------------------663.4.3 引水人力與技術的挑戰-------------------

--------------------------------683.4.4 法規制度的全面檢討-----------------------------------------------------72第四章 精進策略探討-----------------------------------------------------------744.1 臺灣港埠引水安全關鍵因素—思維變異---------------------------------------754.1.1 引水人與船長之合作關係------------------------------------------

-------764.1.2 引水人與VTS之合作關係--------------------------------------------------774.1.3 拖船使用觀念的釐清-----------------------------------------------------784.1.4 引水人與帶解纜業者之合作關係--------------------------------------------814.1.5 引水作業程序化---------------------------------------------------------824.2 臺灣港埠

引水安全關鍵因素—制度調整---------------------------------------844.2.1 拖船制度調整-----------------------------------------------------------884.2.2 建構大區域性引水人制度--------------------------------------------------944.2.3 確立VTS之公權力地位----------------------------------------------------984.2.4 強化引水人自律機制--------------

---------------------------------------994.3 臺灣港埠引水安全關鍵因素—環境優化--------------------------------------1004.3.1 檢視臺灣助導航設施現況效益---------------------------------------------1014.3.2 強化科技化助導航設施--------------------------------------------------1054.3.3 優化VTS----------------------------------------------

----------------1114.4 臺灣港埠引水安全關鍵因素—船舶適航--------------------------------------1164.4.1 從國際法與國內法尋求改善船舶適航的辦法----------------------------------1174.4.2 從案例探討------------------------------------------------------------1234.5 臺灣港埠引水安全關鍵因素—技術強化--------------------------------------1254.5.1 引水作業時之團隊合作

--------------------------------------------------1254.5.2 IMO A.960之建議------------------------------------------------------1294.5.3 拖船技術及效率提升----------------------------------------------------1304.5.4 VTS技術提升----------------------------------------------------------1324.5.5 引水人技術提升-----------

---------------------------------------------133第五章 結論與討論------------------------------------------------------------1405.1 結論-----------------------------------------------------------------1405.2 討論-----------------------------------------------------------------141參考文獻 -----------------------

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