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The Drowners

為了解決String to number js的問題，作者Galloway, Ian 這樣論述：

When Mike discovers a message directing him to an abandoned car, he has no way of knowing his life is about to fall off a precipice. After losing everything he cares about, very nearly including his mind and his life, he decides to fight back against the forces that are intent on destroying him. Mr

Clarke, a loner with a terrifying past, lives his life according to a chart. A chart on which he logs every insult, slight and perceived attack upon himself. A chart he uses to redress the balance. And also a chart that could end up destroying the lives of everyone its owner comes into contact with.

Spoon has a dream. To leave his dead-end existence, to get out of the filthy squat he shares with his so-called friends and to finally make a life for himself. The only problem is, the world and those in it seem determined to rise up and thwart his every move. Set over a three-week period, The Drow

ners is a tale about revenge. It is an account of how lives are consumed, twisted and ultimately destroyed by hatred and the desire for retaliation. It is also the tale of how from seemingly impossible odds, people can overcome all obstacles in their path to achieve their dreams. By turns shocking,

poignant and laugh out loud funny, The Drowners could be the life of the Count of Monte Cristo, if he had been brought up on cheap drugs and alcohol in 1980's Britain. Ian’s overriding passion is to beguile, scare, moisten the eyes, dry the throat, quicken the heart and most of all entertain peopl

e via the written word. For all of his life he has written in one form or another, has won a number of awards, had stories of various length, ambition and quality printed in assorted magazines, publications and anthologies, and has a string of successful books published under a variety of pseudonyms

. The Drowners is the first one published under his own name, and heralds a new talent on the contemporary writing scene.

Nigeria’’s Space Journey: Understanding its Past, Reshaping its Future

為了解決String to number js的問題，作者Abiodun, Adigun Ade 這樣論述：

ABOUT THE BOOK "Nigeria's Space Journey - Understanding its Past, Reshaping its Future" is about space and its impact on a developing country, with Nigeria as a case study. The book focuses on the steps Nigeria is taking to achieve its space and related goals; it is divided into six main sections: S

pace in Human Lives; Space Efforts in Nigeria; Reawakening of Nigeria; Nigeria's Space Priorities; Contributions to the Resolution of Global Concerns; and Moving Ahead. When, in 1962, a 40-pound meteorite from Mars - named Zagami - landed in Nigeria, it was a significant space encounter for the nati

on. Soon after, in 1963, was the equally historic first ever live satellite telephone conversation between America's then youngest President and Nigeria's first Prime Minister. Was space beckoning? Nigeria eventually took the plunge in 2001 and defined its space objective in these words: "To make Ni

geria build indigenous competence in developing, designing and building appropriate hardware and software in space technology as an essential tool for its socio-economic development and enhancement of the quality of life of its people." However, instead of pursuing the above objective, Nigeria swall

owed the bait of the satellite merchants that touted the acquisition of micro-satellites as the quickest and cheapest way to space for the developing countries. With a focus on the upstream-end of the technology, a string of such acquisitions soon became the centrepiece of the nation's space program

me, acquisitions which have taken the nation off course and away from attaining the goals articulated in the above national space objective. The book examines and analyses the lessons Nigeria has learned on such a space journey, to-date. It concludes that the nation's space efforts have not delivere

d as promised and that the nation's space journey should be redefined and redesigned for Nigeria to attain its space and related goals. As Nigeria looks to the future, it must effectively utilise its natural endowments to earn its badge of honour as a space capable country, with an initial focus on

the downstream impact of the technology. Thus, it would need to retool its own science and technology (S&T) capabilities and utilise these assets to enhance its economic development and improve the wellbeing of its people. The book draws on a number of examples from other nations and addresses how N

igeria could learn and benefit from their experience. Nigeria's steadfast commitment to the adoption and implementation of the proposed priorities in this book will enable it to secure its passport to its own future as a knowledge society and a developed country. It will also empower the nation to s

hape its own space and economic future, become a leading partner and voice in determining Africa's future, and be a reliable collaborator in the solution of global problems. By conscientiously following these approaches, Nigeria should be able to proclaim, in the near future, that "Space is our oper

ational tool of development." ABOUT THE AUTHOR: Adigun Ade Abiodun was educated in Nigeria, the USA, and Canada. He obtained his PhD in 1971, in civil engineering from the University of Washington, Seattle, USA, and was a post-doctoral research fellow at the Canada Centre for Remote Sensing in Ott

awa (December 1974 - February 1976). From his academic post at the University of Ife (UNIFE), he was seconded, in 1977, by the Nigerian government, to the United Nations Outer Space Affairs Division (OSAD) in New York, since renamed United Nations Office for Outer Space Affairs (UN-OOSA) and relocat

ed in Vienna, Austria. He was appointed as the United Nations Expert on Space Applications in 1981; he served the organization in that capacity until his retirement in September 1999. Thereafter, he continued with his international engagements, including: Member of the College of Commissioners of th

e United Nations Monitoring, Verification and Inspection Commission on Iraq (UNMOVIC), (2000-2007), and as the Senior Special Assistant (to the President of Nigeria) on Space Science and Technology (March 2000 - May 2003). He also served as the Chairman of the United Nations Committee on the Peacefu

l Uses of Outer Space (June 2004 - June 2006). He is a member of the Board of Directors, World Space Week Association (WSWA), which he once chaired. He is currently a member of the African Union Space Working Group. Ade Abiodun has lectured and published extensively on different aspects of space sci

ence and technology. He is the author of ’Nigeria’s Space Journey - Understanding its Past, Reshaping its Future’ (May 2017), and founder of the African Space Foundation.

子宮內膜樣細胞癌化機轉初探-- 以子宮內膜異位相關卵巢癌及子宮內膜癌為例

為了解決String to number js的問題，作者唐逢翔 這樣論述：

正常而言，子宮內膜細胞只存在於子宮內膜。子宮內膜組織分為基底層與功能層。在女性進入青春期至更年期的這段期間，會隨著卵巢賀爾蒙排卵周期的變化而產生增殖期、分泌期不同的變化。當排卵後沒有受孕，功能層就會脫落排出體外而產生月經，基底層則預備下一次的周期變化。然而，在其他影響婦女健康的疾病中，卻有著類似子宮內膜細胞的變化。這些不是正常子宮內膜細胞存在的位置所產生的病變，特稱為子宮內膜樣細胞病變，其中最有名者乃｢子宮內膜異位症｣及｢子宮內膜樣癌｣，造成婦女健康的莫大傷害。子宮內膜異位症(endometriosis)為好發於育齡婦女的良性疾患。雖然其在病理表現上為良性疾患，但是高達七成五在停止治療後會復

發。而病理切片中有時發現同時存在子宮內膜異位症及卵巢癌的病灶，暗示著子宮內膜異位症可能惡性病變而成為癌症。此外，流行病學的研究指出，罹患子宮內膜異位症的患者將來罹患卵巢癌的機會也會增加。子宮內膜癌(uterus endometrioid adenocarcinoma)為美國女性最常見的婦科癌症。而在台灣，根據國民健康署的癌症登記資料顯示，子宮內膜癌也從2005年的1031例增長到2018年的2439例，為近十年來增長最快速的婦科癌症。子宮內膜樣癌，不論是在子宮內(子宮內膜癌)或子宮外(卵巢子宮內膜樣癌)，在臨床上有類似的型態與行為，並且流行病學上的危險因子也相似。有學者提出假設其來源均為不健康

的子宮內膜細胞。因此，我們透過不同的研究模式，期望能找出子宮內膜樣細胞癌化的可能共同路徑。首先，我們以基因轉殖鼠模式探討子宮內膜異位相關卵巢癌的可能機轉。前人研究發現可能有三種機轉：(1)染色絲整修路徑(Chromatin Remodeling Pathway)、(2)PI3K-AKT mTOR路徑、(3)DNA修復、細胞週期控制及細胞凋亡路徑。而在小鼠模式中，我們發現：(1)合併p53loxP/loxP基因突變及LSL-K-rasG12D/+的活化可導致卵巢子宮內膜樣癌的發生、(2)K-rasG12D/+p53loxP/loxP會誘發卵巢產生子宮內膜樣病灶、(3)K-rasG12D/+p53

loxP/loxP在小鼠卵巢表皮上皮可引致卵巢癌惡性肉瘤(Carcinosarcoma)的發生，是臨床上罕見但相當惡性的卵巢癌，過去並沒有相關的動物模式被建立。其次，我們採取子宮內膜腺癌患者的病灶切片，以次世代定序技術對比腫瘤區與非腫瘤區mRNA與miRNA的表現，並以生物資料庫搜尋可能機轉。我們發現hsa-miR-127-5p的負調控導致CSTB的正調控及hsa-miR218-5p的正調控導致HPGD的負調控與子宮內膜腺癌的形成有關。並且，用KEGG路徑分析STRING中的失調基因顯示，人類乳突病毒感染在其中是最顯著的相關路徑，暗示人類乳突病毒在子宮膜癌的生成中扮演可能的角色。而透過DAVI

D資料庫的分析也顯示病毒感染與子宮內膜癌有關。我們根據實驗結果及文獻，認為當子宮內膜細胞因外在因素(如人類乳突病毒感染)或內在因素(基因易感性、內生性女性荷爾蒙)引起子宮內膜表皮細胞變化(主要為KRAS基因密碼子12及13的點突變)，造成細胞移行與分化的能力上升，且細胞凋亡、壞死與死亡能力受抑制。此種細胞若在子宮內膜，因著CTNNB1、KRAS及POLE突變而造成PI3K-AKT路徑的活化，將導致第一型子宮內膜癌的發生。若此種細胞隨著經血逆流至骨盆腔，加上其他因素如免疫物質刺激、氧化壓力、局部鐵質負擔等，就會產生子宮內膜異位症。如果子宮內膜異位細胞產生ARID1A、KRAS、PTEN、PIK3

CA、MLH1及β-catenin的突變，則容易產生癌變，成為卵巢子宮內膜樣癌。若是KRAS突變加上P53 丟失，則可能形成卵巢癌惡性肉瘤。