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HBase應用大神：OpenTSDB時序式資料庫詳解

為了解決Meta tag的問題，作者百里燊 這樣論述：

　　OpenTSDB 是一個分散式、可伸縮的時間序列資料庫，其底層儲存以HBase 為主，目前版本也支援Cassandra等儲存。正因為其底層儲存依賴於HBase，其寫入效能和可擴充性都獲得了保障。OpenTSDB 支援多tag 維度查詢，支援毫秒級的時序資料。 　　本書共 8 章，主要從原始程式角度深入剖析OpenTSDB 的原理和實現。 　　包括OpenTSDB的網路層、OpenTSDB中UniqueId元件的原理、OpenTSDB如何實現時序資料的存儲及相關優化、OpenTSDB如何實現時序資料的查詢、OpenTSDB中的中繼資料及Tree結構的實現和功能、Ope

nTSDB中的外掛程式及工具類實現原理內容。 　　各章之間的內容相對獨立，對OpenTSDB 有一定了解的讀者可以有目標地選擇合適的章節開始閱讀。 　　本書主要以OpenTSDB 的最新版本（2.3.1 版本）為基礎介紹。                                       　　本書主要內容： 　　■ 快速入門 　　■ 網路層    　　■ UniqueId 　　■ 資料儲存 　　■ 資料查詢 　　■ 中繼資料 　　■ Tree 　　■ 外掛程式及工具類別 　　適合讀者群：對時序資料庫感興趣的讀者。 本書特色 　　OpenTSDB 是一個分散式、可伸縮的時間序列

資料庫，本書從原始程式角度深入剖析OpenTSDB 的原理和實現。  

Meta tag進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決Meta tag的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

必備單詞15000，學完就會用

為了解決Meta tag的問題，作者（韓）金東穆 這樣論述：

現在，對很多英語學習者來說，通過詞源學習單詞已經成為一種常識，但是很多學習者卻沒有系統學習過詞源。本書適合準備TOEIC、TOEFL、GRE等各種英語考試、需要儲備大量詞彙的學習者。   全書共2個章節。第1章由7節構成，整理了盎格魯-撒克遜首碼、拉丁語首碼、希臘語首碼和表示數位的首碼。第2章是詞根篇，共40節。按照羅馬字母順序排序，方便查找。首先介紹一些重要的詞根，然後聯繫一些補充詞根。每節約介紹12至15個詞根。學習40節後，讀者即可學到近15000個單詞，並且對詞源有一定的瞭解。 CHAPTER1 PREFIX 1. ANGLO-SAXON PREFIX( I ) /

008 BE- BY- EN- FOR- FORE- MIS- 2. ANGLO PREFIXES( II ) / 019 OUT- OVER- UN- UNDER- UP- WITH- 3. LATIN PREFIXES( I ) / 030 AB- AD- AMBI- ANTE- POST- BENEMALE- CIRCUM- CON- 4 LATIN PREFIXES( II ) / 042 COUNTER-, CONTRA- DE- DIS- EX- EXTER-, EXTRA- ININTRA-, INTRO- ENTER-, INTER- OB- PRE- 5. LATIN PR

EFIXES( III ) / 053 PRE- PRO- RE-, RETRO- SE- SUB- SUR-, SUPER- SUPR- TRANS- INFER-,INFRA- ULTRA- PRIM-, PRIN- 6. GREEK PREFIXES / 063 A-, ANA- ANTI- APO- AUTO- CACO- CATA- DIA- DYS- ECTO- ENDOEN-,EM- EXO- EO- ESO- EPI- EU- HYPER- HYPOHOLO- HETERO- HOMO- MISO- PERI- PROTO- PSEUDOSYN- TELE- 7. NUMERI

CAL PREFIXEX / 076 HALF ONE TWO THREE FOUR FIVE SIX SEVEN EIGHT Nine TEN HUNDERD THOUSAND MANY ALL CHAPTER2 ROOT SECTTON 1 / 090 基本詞根 ACT, AG ALI, ALITER 補充詞根 AC, ACR, ACU ACRO AERO AESTHET AGOGUE AGON AGRO, AGRI ALB, ALP ALGIA ALI SECTION 2 / 103 基本詞根 AMOR ANIM 補充詞根 ALT AMBLE ANCE, HANCE ANG, ANX A

NDROS ANTHROPOS ANN, ENN APT, EPT AQUA ARGU SECTION 3 / 116 基本詞根 ARCHY ARCH BAN 補充詞根 ARM ART ASPER ASTRO AUDI AUX, AUG AVI BALL BAR BAS SECTION 4 / 130 基本詞根 CAP, CAPT 補充詞根 CEPHAL 基本詞根 CEIVE, CEPT 補充詞根 BAT BELL BIBE BIBLIOS BIOS BLANC BOL, BL BRACE BREV BURS SECTION 5 / 144 基本詞根 CAD CIDE 補充詞根 CAL CAM

P CAND, CENS CAR CARE, CURE CARN CAUSE, CUSE CAVE CELER CEL SECTION 6 / 157 基本詞根 CEDE, CESS CANT 補充詞根 CELL CENS CENTER CERN CHARGE CAST, CHAST CHIRO CHROM CHRONO CINCT SECTION 7 / 169 基本詞根 CLUDE, CLOSE CORD, CARD 補充詞根 CIRCULARI CITE CIVI CLAR CLAM, CLAIM CLIM CLIN COLL COL CONCH SECTION 8 / 184 基本詞根

CRACY CRE, CRET 補充詞根 CORP COSMOS COVER CRIM, CULP CRIT, CRIS CRUC, CRUX CRYPTOS, COND CUMB, CUMBE, CUB CULT CUSS, SEISM SECTION 9 / 198 基本詞根 CRED CUR, COUR 補充詞根 DACTYLO DAMN DATE DEBT, DEBIT DEI, DIV DENT DERM, DERMAT DEXTER DIGN DI, DIURN SECTION 10 / 212 基本詞根 DEMO, DEMON DIC 補充詞根 DOL DOM, DOMIN D

ON DORM DRESS DROM DUR DYNAM EGO EMPT, EMP SECTION 11 / 226 基本詞根 DOCT DUCERE EQUA, EQUI 補充詞根 ERG, ERGY ERR ESCE ESS EV FACE FAN FARE FEND SECTION 12 / 241 基本詞根 FA FID 補充詞根 FILL FIRM FIX FLAGR FLAT FLEXT, FLEX FLICK, FLICT FLORI FOLI FUND SECTION 13 / 255 基本詞根 FAC FICT 補充詞根 FORT FRACT, FRAG, FRANG FR

ANC, FRANCE, FRANK FRONT FUG FOME GAL GAMOS GASTROS GEOS SECTION 14 / 270 基本詞根 FER FIN 補充詞根 GLOB GON GORGE GRAM GRAPH GRAC,GRAT GRAV GREG HABIT, HAV HAP SECTION 15 / 286 基本詞根 FLU FROM 補充詞根 HELIO HEMATO HERB HERE, HES HERIT HIBERN HYPNO IDENT IDIO IDOL SECTION 16 / 298 基本詞根 FUS GEN 補充詞根 IGN INSUL ISO

ITIS JUD JUR JUS JUVEN LABOR LAC, LACT SECTION 17 / 312 基本詞根 GER, GEST 補充詞根 LAB LAST LATERAL LATRY LAV, LUV, LOT LEN, LENT LEPSY LEV LIBER, LIVER SECTION 18 / 324 基本詞根 GRAD, GRESS HUM, HOM 補充詞根 LINQU,LICT LINGU LIQU LITER LONG LUD LYSIS MACRO MAGN MAJ SECTION 19 / 338 基本詞根 HOR HYDRO 補充詞根 MAN MAND,

MEND MANIA MAR MATER PATER MARC, MARK MAX, MINI MELAN MEL SECTION 20 / 351 基本詞根 JAC, JECT JOIN, JUNCT 補充詞根 MED MEDI, MEDIC MEMO MEN, MENS MIN, MEN MENS, MEAS MENT MERCE MERG, MERS META SECTION 21 / 367 基本詞根 LAT LEG, LECT 補充詞根 METER, METR MIGR MILIT MINISTER MIR MIX,MISC MODE MOL MONIT MONT SECTION 2

2 / 381 基本詞根 LOC LOCUT, LOQU LOGY, LOGUE 補充詞根 MONY MORPH MORT, MORS MUN, MON MUT NAT NARCO NEB, NEPH NECR, NECRO NECT, NEX SECTION 23 / 394 基本詞根 LUC, LUMIN MAN, MANI, MANU 補充詞根 NEG, NEGA NERV, NEURO NOC, NOX NOMY NORM NOTE NOUNCE, NUNC UNMBER, NUMER NUR(S), NUTRI OCUL SECTION 24 / 407 基本詞根 MISS, MIT

MOB, MOV, MOT 補充詞根 HOD, OD ODE ODOR, OL ONT OPER OPT OP OR ORD ORI, ORT SECTION 25 / 421 基本詞根 NAI, NAT NOM, NOMEN 補充詞根 ORTHO OSS, OSTEO OV PAC PAN PART PASS PATH PED PAED, PED SECTION 26 / 435 基本詞根 NOV PAR 補充詞根 PEL, PULS PEN, PUN PEPS PER, PIRE PAT, PET PHAY PHALL PHOB PHILO PHOTO SECTION 27 / 449

基本詞根 PAR PEND 補充詞根 PHREN PHYSIO PHYTO PICT PILE PLAC PLAN PLAS PLANT PLU SECTION 28 / 462 基本詞根 PHON PLEN, PLIC 補充詞根 PNEUM POD, PUS PONDER POPUL, PUBL POT PRAIS, PREC PREHEND PRESS PRIS PRIV LECTURE 29 / 476 基礎詞根 PORT PON, POSE 補充詞根 PROB, PROV PROPER PSYCH PTO PUD PUNCT PUGN PUR PUT PYRO SECTION 30 /

492 基本詞根 QUER, QUEST 補充詞根 ROG QUIET RADIC RADI RANGE RAP, RAV RAS RAT REPT RRH RHINO LECTURE 31 / 504 基本詞根 RECT, REG SCRIBE, SCRIPT 補充詞根 RID RIV ROB RODE, ROS ROL, ROT RUPT SACR(O),SECR SAG, SAP, SIP SAL SAL, SULT SECTION 32 / 518 基本詞根 SENS, SENT SED, SID, SESS 補充詞根 SANCT SAN, SALUB SANGUIN SATIS S

CAL SCEND SCRE, SCRU SCUT, SQU SEC, SECT SEMBLE SECTION 33 / 530 基本詞根 SERV SIGN 補充詞根 SEMEN, SEMIN SEQUE, SECUT SERT SIMIL SOCI SOLD SOLVE, SOLOTE SOMNUS SOPH SOR SECTION 34 / 543 基本詞根 SPEC, SPECT SPIR, SPER 補充詞根 SORT SPHERE SPOND, SPONS STALL STELL STENO STEREO STICK, STIG STING, STINCT STOM SECTION

35 / 554 基本詞根 SIST, STA STAT, STIT, STIC 補充詞根 STONE STORE STRATO STRI STRU SUE SUM SUM,SUMP SURG SURE SECTION 36 / 569 基本詞根 TEN, TIN, TAIN TEND 補充詞根 TACT, TACH, TAG, TACK, TANG TAIL TAX TEX,TEXT TOX TEG TECHN TEMPO TENU TERG, TERS SECTION 37 / 581 基本詞根 TRA, TRACT VAC, VAG, VOID 補充詞根 TERMIN TERRA TE

RR TEST THE，THEO THERAPY THES, THET TIRE TOM TON, TONE LECTURE 38 / 594 基本詞根 VAL, VAIL VEN, VENT 補充詞根 TOR, TORT TORN, TOUR STRPHE TRIBUTE TRUD,TRUS TUBER, TURN TURB TYPH UMBR UND, OUND SECTION 39 / 606 基本詞根 VERT VIA 補充詞根 URB US, UT VARI VEH VELO VERB VER VIC,VICIS VINC VITA SECTION 40 / 621 基本詞根 VID

VOC VOL 補充詞根 VOL, VOLUN VOLC, VULC VOLVE,VOLU VOR VULG VULS WAR, WARD ZOO ZYMO

應用五味子乙素於曼森血吸蟲感染之相關損傷的治療效果

為了解決Meta tag的問題，作者林皓然 這樣論述：

血吸蟲病（Schistosomiasis）是世界上僅次於瘧疾的最重要的寄生蟲病。臨床上，血吸蟲病患會出現肝臟或其他器官纖維化的症狀。目前，血吸蟲病患者以吡喹酮（Praziquantel；PZQ）治療為主。然而，雖然 PZQ 能有效殺死血吸蟲蟲，它不能防止病患的再次感染或治療肝臟纖維化。而目前的治療方法也不足以治癒肝臟纖維化。除此之外，目前已在眾多體內和體外的研究中發現了血吸蟲對PZQ的抗藥性。因此，我們迫切的需要尋找新的有效治療藥物。目前五味子植物中的五味子乙素（Schisandrin B；Sch B）已被證明可以預防各種不同的肝臟損傷。因此，我們在此研究使用Sch B治療因曼森血吸蟲（Sc

histosoma mansoni）誘發的各種器官損傷的潛力。本研究的結果顯示，Sch B可通過抑制發炎小體的活化和細胞凋亡，以及調節免疫反應，來治療因曼森血吸蟲誘導的肝臟纖維化。此外，Sch B可破壞雄性成蟲，從而有助於減少產卵量並減輕病變。我們進一步的實驗發現，PZQ-Sch B 治療可對血吸蟲病產生更有效的治療反應。這種治療策略可以保護與曼森血吸蟲感染相關的器官損傷，包括肝臟、脾臟、腸道和肺部。此外，PZQ-Sch B的治療提高了感染小鼠的存活率，並且達到更好的預後。總的來說，Sch B對於治療血吸蟲病相關的肝臟損傷和全身併發症可能是一個很有效的藥物。