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How the American Elites Won, Lost, and Can Win Again: From the Moon Landing to Coronavirus

為了解決American Standard的問題，作者Buskirk, Christopher 這樣論述：

Between 1920 and 1950, America saw an unprecedented expansion of wealth and power underwritten by technological innovation, cultural confidence, and victory in war. American elites won World War II, rebuilt the world order with America at its head, inaugurated the jet age, and put a man on the mo

on. The boom led to a larger, richer middle class that confirmed America’s best ideals. By the early 1970s, that ended. American elites have captured a disproportionate share of the social and economic rewards over the last fifty years. Meanwhile, the middle class has shrunk in size and has become e

conomically insecure, owning a smaller share of national wealth than at any time in the nation’s history. This has happened even while most households have two income earners, versus the single-income households that characterized the period of shared prosperity. At the same time, technological inno

vation that improves people’s standard of living has dramatically slowed. These trends undermine the basic premise behind the broad acceptance of a meritocratic elite, whose rule is predicated on the belief that if the best rise to the top, their talent and energy will create a rising tide that lift

s all boats. We had that once. We can have it again.

American Standard進入發燒排行的影片

An Integrated Approach For Uncovering Novel DNA Methylation Biomarkers For Non-small Cell Lung Carcinoma

為了解決American Standard的問題，作者VAIBHAV KUMAR SUNKARIA 這樣論述：

Introduction - Lung cancer is one of primal and ubiquitous cause of cancer related fatalities in the world. Leading cause of these fatalities is non-small cell lung cancer (NSCLC) with a proportion of 85%. The major subtypes of NSCLC are Lung Adenocarcinoma (LUAD) and Lung Small Cell Carcinoma (LUS

C). Early-stage surgical detection and removal of tumor offers a favorable prognosis and better survival rates. However, a major portion of 75% subjects have stage III/IV at the time of diagnosis and despite advanced major developments in oncology survival rates remain poor. Carcinogens produce wide

spread DNA methylation changes within cells. These changes are characterized by globally hyper or hypo methylated regions around CpG islands, many of these changes occur early in tumorigenesis and are highly prevalent across a tumor type.Structure - This research work took advantage of publicly avai

lable methylation profiling resources and relevant comorbidities for lung cancer patients extracted from meta-analysis of scientific review and journal available at PubMed and CNKI search which were combined systematically to explore effective DNA methylation markers for NSCLC. We also tried to iden

tify common CpG loci between Caucasian, Black and Asian racial groups for identifying ubiquitous candidate genes thoroughly. Statistical analysis and GO ontology were also conducted to explore associated novel biomarkers. These novel findings could facilitate design of accurate diagnostic panel for

practical clinical relevance.Methodology - DNA methylation profiles were extracted from TCGA for 418 LUAD and 370 LUSC tissue samples from patients compared with 32 and 42 non-malignant ones respectively. Standard pipeline was conducted to discover significant differentially methylated sites as prim

ary biomarkers. Secondary biomarkers were extracted by incorporating genes associated with comorbidities from meta-analysis of research articles. Concordant candidates were utilized for NSCLC relevant biomarker candidates. Gene ontology annotations were used to calculate gene-pair distance matrix fo

r all candidate biomarkers. Clustering algorithms were utilized to categorize candidate genes into different functional groups using the gene distance matrix. There were 35 CpG loci identified by comparing TCGA training cohort with GEO testing cohort from these functional groups, and 4 gene-based pa

nel was devised after finding highly discriminatory diagnostic panel through combinatorial validation of each functional cluster.Results – To evaluate the gene panel for NSCLC, the methylation levels of SCT(Secritin), FOXD3(Forkhead Box D3), TRIM58(Tripartite Motif Containing 58) and TAC1(Tachikinin

1) were tested. Individually each gene showed significant methylation difference between LUAD and LUSC training cohort. Combined 4-gene panel AUC, sensitivity/specificity were evaluated with 0.9596, 90.43%/100% in LUAD; 0.949, 86.95%/98.21% in LUSC TCGA training cohort; 0.94, 85.92%/97.37 in GEO 66

836; 0.91,89.17%/100% in GEO 83842 smokers; 0.948, 91.67%/100% in GEO83842 non-smokers independent testing cohort. Our study validates SCT, FOXD3, TRIM58 and TAC1 based gene panel has great potential in early recognition of NSCLC undetermined lung nodules. The findings can yield universally accurate

and robust markers facilitating early diagnosis and rapid severity examination.

The Peacemaker: Ronald Reagan in the White House and the World

為了解決American Standard的問題，作者Inboden, William 這樣論述：

An in-depth and masterful account of how Ronald Reagan’s foreign policy team of rivals won the Cold War and laid the foundation for the twenty-first century.Today, the ending of the Cold War seems a foregone conclusion. But in the early 1980s, US intelligence and other experts believed the Soviet Un

ion was strong, stable, and would last into the next century. Ronald Reagan entered the White House with no certainty of what would happen next, only an overriding faith in American democracy and an abiding belief that the communist system--and the threat of nuclear war--must be brought to an end. T

he Peacemaker is the story of the eight years of Reagan’s presidency, as he and his national security team managed, in real time, multiple crises around the globe. From the emergence of global terrorism, wars in the Middle East, the rise of Japan and the awakening of China, to proxy conflicts in Lat

in America, Africa, and Asia, Reagan’s team oversaw the worldwide expansion of democracy, globalization, free trade, and the information revolution. Yet no issue was greater than the Cold War standoff with the Soviet Union. As president, Reagan cast aside the four-decades-old policy of containment a

nd challenged the Soviets in an arms race and ideological contest that pushed them towards economic and political collapse, all while extending an olive branch of diplomacy. Reagan’s revolving team included Secretaries of State Al Haig and George Schultz; Secretaries of Defense Caspar Weinberger and

Frank Carlucci; National Security Advisors Bill Clark, John Poindexter and Bud McFarlane; Chief of Staff James Baker; CIA Director Bill Casey; and United Nations ambassador Jeane Kirkpatrick. Talented and devoted to their cause, at times their inner rivalries and backstabbing led to missteps and cr

ises. But over the course of the administration, Reagan and his team developed the strategies that brought us to the brink of the Cold War’s peaceful conclusion, and remade the world. William Inboden is executive director of the Clements Center for National Security and Associate Professor of Publ

ic Policy and History at the LBJ School, both at the University of Texas at Austin. Prior to academia, he worked for fifteen years as a policymaker in Washington, DC and overseas, including senior positions with the State Department and the National Security Council in the George W. Bush Administrat

ion. A graduate of Stanford University, he earned his doctorate at Yale. He is a life member of the Council on Foreign Relations, and his commentary has appeared in numerous outlets including the Wall Street Journal, New York Times, Washington Post, Los Angeles Times, Foreign Affairs, Foreign Policy

, Weekly Standard, World, NPR, CNN, Sky News, and BBC.

NFT非同質化代幣購買意圖之研究

為了解決American Standard的問題，作者陳奕達 這樣論述：

隨著第三次科技革命的日趨發展，快速的進入了數位化時代，也為生活中帶來了一些改變。尤其是交易方式、商品性質的改變尤其明顯，如光碟、書籍、圖畫等，以前都要到實體店面購買，現在大家只要動動手指就可以在網路上完成整個交易；另外，還有推出數位形式供大家選購，不在侷限於商品本身的框架。NFT是將金錢、互聯網這兩個元素融合而產生出一個新的名詞。而這個名詞在這兩年不斷地廣流傳在網路、大小媒體上面，同時也獲選為2021「年度十大代表關鍵字」的冠軍，使得眾多藝術家、運動品牌、偶像名人甚至是時尚品牌都開始默默地投入NFT市場，這也提供給消費者在NFT市場上有更多的選擇。本研究以S-O-R理論為基礎，目的為探討消費

者在對於「美學觀」、「品牌知名度」、「行銷活動」、「知覺價值」、「知覺信任」、「購買意圖」及「口碑推薦」的關係之研究，並透過問卷調查方式，統計一般消費者對於NFT購買意圖的意見，並分析消費者在受到各種外在刺激構面後，個體心理的變化以及對購買意圖之關聯。研究問卷共計回收400份問卷，有效問卷數為365份，有效問卷回收率為91.3%。研究結果發現：消費者受到NFT的「外部刺激」因素後，對「自我知覺」有正向顯著的影響、消費者的「自我知覺」對於NFT「購買意圖」有正向顯著的影響、消費者的「自我知覺」對於NFT「口碑推薦」有正向顯著的影響、消費者的「自我知覺」對於「外部刺激」與「購買意圖」有起到中介的效

果。