Alternative splicing的問題，透過圖書和論文來找解法和答案更準確安心。 我們找到下列推薦必買和特價產品懶人包

Human Genetics and Genomics: A Practical Guide

為了解決Alternative splicing的問題，作者Taneri, Bahar,Asilmaz, Esra,Delikurt, T?rem 這樣論述：

Finally meeting the need for a laboratory manual on human genetics, this practical guide is the perfect companion title to all major standard textbooks on the subject. The authors all have a high-level research background and are actively involved in teaching and counseling. Based on a standard cur

riculum in human genetics, each chapter equals one practical unit of the course and topics range from basics in human inheritance to genetics in major disease clusters and from bioinformatics and personalized medicine to genetic counseling. Bahar Taneri is an Associate Professor of Molecular Biolo

gy and Genetics at Eastern Mediterranean University (EMU), Famagusta, Cyprus. After obtaining her Ph.D. degree from The Rockefeller University, New York, USA, in 2005, she has taught undergraduate and graduate level Genetics and Genomics modules at EMU, where she has served as the editor-in-chief of

the university Research Newsletter for two years. At EMU, she has also been chairing the Department of Biological Sciences since 2013. She is an affiliated Researcher of the Institute of Public Health Genomics, Faculty of Health, Medicine & Life Sciences at Maastricht University, The Netherlands, s

ince 2011. She authored several publications in the field of genome biology and alternative splicing and received several awards including a Fulbright Scholarship. Currently, her main research interests include public health genomics approaches for prevention of common complex diseases. Esra Asilma

z is currently a Specialty Registrar in Gastroenterology at Homerton University Hospital in London, UK. She obtained her Ph.D. degree in Molecular Genetics from The Rockefeller University, New York, USA in 2004. She subsequently obtained her Bachelor of Medicine, Bachelor of Surgery degree in 2009 f

rom St. George’s University of London, UK. In between 2009 to 2011, she completed an Academic Foundation Programme at St. Thomas’ and Guy’s Hospital, London, UK. During this time, she worked at Professor Trembath’s Laboratory of Human Genetics and was involved in the identification of Notch2 mutatio

ns in Hadju-Cheney Syndrome, a rare genetic condition. She was an Academic Clinical Fellow at University College Hospital, London, UK, in between 2011 to 2014 and was a member of Dr. Oben’s laboratory at The Institute of Liver and Digestive Health. She obtained her MRCP (UK) Diploma in 2014. Turem

Delikurt graduated with a BSc in Biology from the University of South Dakota, USA, in 2003. She completed her MSc in Genetic Counselling with a merit from the University of Manchester, UK, in 2006. She has been working as a genetic counsellor in Cyprus since 2006. In 2015, she was registered by the

European Board of Medical Genetics. Her main research interest is the exploration of genetic counselling in the context of culture. She is currently pursuing her Ph.D. degree, which is sponsored through the University of Plymouth, UK, entitled ＂Genetic Counselling in the Turkish Cypriot community＂.

Since 2004, she has been penning a weekly column titled ＂Genetics Today＂ at one of the main newspapers in North Cyprus, which aims to increase the general public’s awareness about genetics and genetic technology. Over the years, she has been continuosly involved in various civil society activities a

imed at increasing the quality of care and life of patients/families at risk of or affected by genetic conditions in Cyprus. Pembe Savas obtained her undergraduate degree in Medical Biochemistry from University of Leicester, UK, in 2011 and further received an MSc degree in Reproductive Science and

Women’s Health at University College London, UK, in 2012. She has completed her project on pre-implantation genetic diagnosis of beta-thalassaemia at Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus, in 2012, where she gained hands-on laboratory experience. Since 2013, Pembe Savas is wor

king as a senior instructor in the Department of Biological Sciences at the Eastern Mediterranean University, Famagusta, Cyprus, where she is responsible for teaching numerous modules for the Molecular Biology and Genetics program. Currently, she is working towards a Ph.D. degree in the Institute of

Public Health Genomics, Faculty of Health, Medicine & Life Sciences at Maastricht University, The Netherlands. Her research topic focuses on genetic testing in common complex diseases. Seniye Targen obtained her undergraduate degree in Human Genetics from Newcastle University, UK, in 2009 and furt

her specialized in the field of Human Molecular Genetics at Imperial College London, United Kingdom, in 2010, where she completed a project on X-linked cataract and Nance-Horan Syndrome. Upon completing her graduate degree, she has gained experience in private medical diagnostic laboratories. She ha

d been employed as a laboratory instructor in the Department of Biological Sciences at the Eastern Mediterranean University, Famagusta, Cyprus, from 2013 to 2015. Currently, she is working towards a Ph.D. degree in the field of breast cancer biology at Bilkent University, Ankara, Turkey. Yagmur Ese

men is in the process of completing her post-graduate entry Bachelor of Medicine, Bachelor of Surgery degree from St. George’s University of London, UK. In 2013, she completed her undergraduate degree with a double major in Neuroscience and Biology at Lawrence University, WI, USA. She has been invol

ved in various research projects in the fields of neuroscience, biochemistry, molecular biology and genetics. She has worked at Mayo Clinics, Rochester, MN, USA studying the effects of Bro1 family members on Vps4 activity. Her senior thesis examining the neural targets of DAF-19 in C. elegans was aw

arded suma cum laude honors. She has worked as a laboratory instructor in the Department of Biological Sciences at the Eastern Mediterranean University, Famagusta, Cyprus. She has received several honors including the Howard and Helen Russell Award for Excellence in Biological Sciences.

Computational Methods for Next Generation Sequencing Data Analysis

為了解決Alternative splicing的問題，作者Mandoiu, Ion I. (EDT)/ Zelikovsky, Alexander (EDT) 這樣論述：

Introduces readers to core algorithmic techniques for next-generation sequencing (NGS) data analysis and discusses a wide range of computational techniques and applicationsThis book provides an in-depth survey of some of the recent developments in NGS and discusses mathematical and computational cha

llenges in various application areas of NGS technologies. The 18 chapters featured in this book have been authored by bioinformatics experts and represent the latest work in leading labs actively contributing to the fast-growing field of NGS. The book is divided into four parts: Part I focuses on co

mputing and experimental infrastructure for NGS analysis, including chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling strategies for massive viral sequencing, and high-fidelity sequencing protocols.Part II concentrates on analysis of DNA sequencing data, co

vering the classic scaffolding problem, detection of genomic variants, including insertions and deletions, and analysis of DNA methylation sequencing data. Part III is devoted to analysis of RNA-seq data. This part discusses algorithms and compares software tools for transcriptome assembly along wit

h methods for detection of alternative splicing and tools for transcriptome quantification and differential expression analysis. Part IV explores computational tools for NGS applications in microbiomics, including a discussion on error correction of NGS reads from viral populations, methods for vira

l quasispecies reconstruction, and a survey of state-of-the-art methods and future trends in microbiome analysis.Computational Methods for Next Generation Sequencing Data Analysis: Reviews computational techniques such as new combinatorial optimization methods, data structures, high performance comp

uting, machine learning, and inference algorithmsDiscusses the mathematical and computational challenges in NGS technologiesCovers NGS error correction, de novo genome transcriptome assembly, variant detection from NGS reads, and moreThis text is a reference for biomedical professionals interested i

n expanding their knowledge of computational techniques for NGS data analysis. The book is also useful for graduate and post-graduate students in bioinformatics. Ion Mandoiu, PhD, is an associate professor in the Computer Science and Engineering Department at the University of Connecticut, USA. H

is main research interests are in the design and analysis of approximation algorithms for NP-hard optimization problems, particularly in the area of bioinformatics. Dr. Mandoiu has authored over 100 refereed articles in journals and conference proceedings. He has also co-edited (with A. Zelikovsky)

a book on Bioinformatics Algorithms: Techniques and Applications (Wiley 2008).Alexander Zelikovsky, PhD, is a Distinguished University Professor with the Computer Science Department at the Georgia State University, USA. His research focuses on discrete algorithms and their applications in computatio

nal biotechnology and biology, bioinformatics, VLSI CAD, and wireless networks. Dr. Zelikovsky has authored more than 170 refereed publications. He served as the co-Chair of International Symposium on Bioinformatics Research and Applications (2005-2016) and the Workshop on Computational Advances in

Next-Generation Sequencing (2011-2015).

應用五味子乙素於曼森血吸蟲感染之相關損傷的治療效果

為了解決Alternative splicing的問題，作者林皓然 這樣論述：

血吸蟲病（Schistosomiasis）是世界上僅次於瘧疾的最重要的寄生蟲病。臨床上，血吸蟲病患會出現肝臟或其他器官纖維化的症狀。目前，血吸蟲病患者以吡喹酮（Praziquantel；PZQ）治療為主。然而，雖然 PZQ 能有效殺死血吸蟲蟲，它不能防止病患的再次感染或治療肝臟纖維化。而目前的治療方法也不足以治癒肝臟纖維化。除此之外，目前已在眾多體內和體外的研究中發現了血吸蟲對PZQ的抗藥性。因此，我們迫切的需要尋找新的有效治療藥物。目前五味子植物中的五味子乙素（Schisandrin B；Sch B）已被證明可以預防各種不同的肝臟損傷。因此，我們在此研究使用Sch B治療因曼森血吸蟲（Sc

histosoma mansoni）誘發的各種器官損傷的潛力。本研究的結果顯示，Sch B可通過抑制發炎小體的活化和細胞凋亡，以及調節免疫反應，來治療因曼森血吸蟲誘導的肝臟纖維化。此外，Sch B可破壞雄性成蟲，從而有助於減少產卵量並減輕病變。我們進一步的實驗發現，PZQ-Sch B 治療可對血吸蟲病產生更有效的治療反應。這種治療策略可以保護與曼森血吸蟲感染相關的器官損傷，包括肝臟、脾臟、腸道和肺部。此外，PZQ-Sch B的治療提高了感染小鼠的存活率，並且達到更好的預後。總的來說，Sch B對於治療血吸蟲病相關的肝臟損傷和全身併發症可能是一個很有效的藥物。